Comparison of Unstimulated In Vitro Maturation and Stimulated In Vitro Fertilization in Women with Poly Cystic Ovarian Syndrome

Background: In regard to complications of controlled ovarian hyperstimulation (COH) such as multiple pregnancy and ovarian hyper stimulation syndrome (OHSS) and other short and long term complications, the interest to In Vitro Maturation (IVM) of oocytes from unstimulated ovaries is increasing. This clinical trial study was designed to establish the relative success of treatment with IVM in comparison with In Vitro Fertilization (IVF) in Poly Cystic Ovarian Syndrome (PCOS) women. Methods: This prospective clinical trial included 35 IVM and 35 IVF cycles matched for age, and duration and cause of infertility. IVM patients underwent transvaginal retrieve of immature oocytes during unstimulated cycles, IVM and ICSI. Those in IVF group underwent ovarian stimulation after pituitary supression. Main outcome measures included number of retrieved oocytes, number of produced embryos, and pregnancy rate and complications. Results: In the IVM group, 1.39 mature oocytes, 0.27 fertilized oocyte, and 0.24 embryos were obtained per retrieval, and in IVF group, 8.45 mature oocytes, 3.8 fertilized oocytes, and 2.7 embryos were obtained. Conclusion: This significant differences between two groups (P~ 0) indicate that this method maybe used as a research setting until further study.